Asbestos-related Pleural Disease due to Tremolite Associated with Progressive loss of Lung Function: Serial Observations in 123 miners, Family Members, and Residents of Libby, Montana

Asbestos-related Pleural Disease due to Tremolite Associated with Progressive loss of Lung Function: Serial Observations in 123 miners, Family Members, and Residents of Libby, Montana

ABSTRACT
Background: The community of Libby, Montana has recently been the focus of national attention secondary to widespread amphibole contamination associated with vermiculite mining and processing.

Methods: Patients who had occupational and non-occupational exposure to amphibole asbestos in Libby, Montana were evaluated for progressive loss of pulmonary function.

Results: Of the 123 participants evaluated, 94 demonstrated average age-corrected accelerated loss per year of vital capacity at 3.2%, total lung capacity (TLC) 2.3%, and DLCO 3.3%. All participants all had predominantly pleural changes with minimal to no interstitial disease.

Conclusions: The study demonstrates a progressive loss of pulmonary function in participants exposed to tremolite asbestos.

AUTHORS
Alan C. Whitehouse